Comparison of in-vitro Antibiotic Susceptibility of Ciprofloxacin, Cefotaxime, Ceftazidime and Cefepime against Gram Negative Bacilli Infections - A Study from Tertiary Care Centre

Introduction: Infections from gram negative bacilli is a challenge for clinicians and laboratory personnel. Treatment of these infections remained as an area concern. Both fluroquinolones cephalosporins are most common choice antibiotics. Despite Cephalosporins, being drug they expensive also showed many adverse reactions. This study, compares reevaluates the susceptibility bacteria to (ciprofloxacin) compared cephalosporins. Method: Various samples(pus, sputum, urine, blood bodyfluids) were processed according standard protocols. Antibiotic done by using Kirby-baur disc diffusion method. ESBL Amp C producers identified CLSI guidelines. Result: Among 400 isolates, majority pus followed sputum. The organism isolated was Klebsiella spp, (33.25%) Escherichia coli (29.5%), Pseudomonas spp (27.25%), Enterobacter (6.25%), Citrobacter 5 (1.25%), Acinetobacter (2.5%). Isolates 20-80% ciprofloxacin, 30-60% third fourth generation 64% 31% ciprofloxacin. 30% cefipime 20% 34 isolates 18 AmpC producers, which 15(44%) 7(38%) ciprofloxacin susceptible. Conclusion: Ciprofloxacin found be more effective than cephalosporin (cefepime) against bacilli. can considered treatment it active cost when Keywords: Fluroquinolones, Multidrug resistant, ESBL,